Zinc finger and BTB domain-containing protein 46

Property Summary

NCBI Gene PubMed Count	10
PubMed Score	11.06

PubTator Score	4.34

Knowledge Summary

Patent

No data available

TINX Plot

Disease (3)

Disease	Target Count	P-value
atypical teratoid / rhabdoid tumor	5112	3.1e-06
osteosarcoma	7950	3.9e-05
ovarian cancer	8520	2.5e-03
sonic hedgehog group medulloblastoma	467	1.1e-02
glioblastoma	5792	1.6e-02
adult high grade glioma	3801	2.3e-02
medulloblastoma, large-cell	6241	3.0e-02
subependymal giant cell astrocytoma	2287	3.6e-02

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.8

Disease	Target Count	Z-score	Confidence
Multiple Sclerosis	540	0.0	2.7

Differential Expression (8)

Disease	log2 FC	p
adult high grade glioma	-1.100	2.3e-02
atypical teratoid / rhabdoid tumor	-1.700	3.1e-06
glioblastoma	-1.200	1.6e-02
medulloblastoma, large-cell	-1.300	3.0e-02
osteosarcoma	-2.985	3.9e-05
ovarian cancer	1.600	2.5e-03
sonic hedgehog group medulloblastoma	1.200	1.1e-02
subependymal giant cell astrocytoma	-2.149	3.6e-02

Brain - Cerebellum 17,983

Spleen 17,614

Brain - Cerebellar Hemisphere 18,015

Ovary 17,971

Uterus 17,618

Thyroid 18,024

Pituitary 18,147

Nerve - Tibial 18,007

Adipose - Visceral (Omentum) 17,937

Breast - Mammary Tissue 18,103

Lung 18,057

Adipose - Subcutaneous 18,110

Kidney - Cortex 17,329

Prostate 18,213

Testis 18,518

Adrenal Gland 18,071

Esophagus - Gastroesophageal Junction 18,000

Brain - Cortex 18,039

Vagina 17,834

Esophagus - Muscularis 18,017

Brain - Frontal Cortex (BA9) 18,069

Artery - Coronary 17,949

Small Intestine - Terminal Ileum 17,954

Colon - Sigmoid 18,089

Brain - Anterior cingulate cortex (BA24) 17,989

Heart - Atrial Appendage 17,896

Artery - Aorta 17,896

Heart - Left Ventricle 18,006

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Hypothalamus 18,169

Liver 18,071

Brain - Caudate (basal ganglia) 18,001

Skin - Sun Exposed (Lower leg) 17,968

Minor Salivary Gland 18,005

Brain - Amygdala 18,006

Skin - Not Sun Exposed (Suprapubic) 18,081

Stomach 17,879

Brain - Putamen (basal ganglia) 17,863

Esophagus - Mucosa 18,076

Colon - Transverse 17,825

Brain - Hippocampus 18,011

Brain - Spinal cord (cervical c-1) 17,973

Artery - Tibial 17,631

Brain - Substantia nigra 17,981

Muscle - Skeletal 17,778

Cells - EBV-transformed lymphocytes 18,186

Pancreas 18,123

Cells - Transformed fibroblasts 17,577

Whole Blood 17,439

B Cells 9,086

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Cervical carcinoma cell 4,944

Erythroleukemia cell 4,300

Prostate gland epithelium 457

See source...

Dendritic cell 4

See source...

Synonym

Accession	Q86UZ6 E1P5K9 Q5JWJ3 Q6GMV4 Q9BQK3 Q9H3Z8 Q9H3Z9
Symbols	BZEL BTBD4 RINZF ZNF340 dJ583P15.7 dJ583P15.8

Gene

ZBTB46

PANTHER Protein Class (3)

cytoskeletal protein 441

actin family cytoskeletal protein 221

non-motor actin binding protein 90

Ortholog (12)

Species	Source	Disease
Mouse 16,570	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Chimp 14,140	OMA EggNOG
Macaque 12,761	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Anole lizard 10,588	Inparanoid OMA EggNOG
Zebrafish 9,726	Inparanoid OMA
Platypus 5,703	Inparanoid OMA EggNOG
Chicken 7,827	Inparanoid OMA EggNOG

UniProt Keyword (13)

Complete proteome 20,231

Metal-binding 3,672

Nucleus 5,259

Polymorphism 12,194

Reference proteome 20,231

Repeat 4,916

Transcription 2,402

Transcription regulation 2,336

Zinc 2,356

Zinc-finger 1,785

See all...

GO Function (2)

metal ion binding 2,256

nucleic acid binding 210

GO Component (1)

nucleus 5,097

GO Process (7)

regulation of transcription, DNA-templat... 1,135

transcription, DNA-templated 1,742

negative regulation of granulocyte diffe... 8

negative regulation of dendritic cell di... 6

negative regulation of macrophage differ... 7

negative regulation of monocyte differen... 7

positive regulation of dendritic cell di... 4

Compartment GO Term (10)

Cell 16,178

Cell part 16,177

Intracellular 14,109

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

Intracellular part 13,972

Nucleus 7,562

Organelle 12,238

cellular_component 18,320

membrane-bounded organelle 11,132

IMPC Phenotype (5)

preweaning lethality, incomplete penetra... 499

decreased vertical activity 208

small testis 58

abnormal seminal vesicle morphology 114

abnormal testis morphology 43

MGI Phenotype (4)

hematopoietic system phenotype 3,383

mortality-aging 5,018

immune system phenotype 3,461

normal phenotype 1,999

GWAS Trait (3)

Coronary artery disease 367

Obesity-related traits 569

Multiple sclerosis 124

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493