| Tbio | Zinc finger and BTB domain-containing protein 46 |
Function as a transcriptional repressor for PRDM1.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7933 | 3.35736190287396E-12 |
| atypical teratoid / rhabdoid tumor | 4369 | 3.06431623928856E-6 |
| ovarian cancer | 8492 | 0.00246176269080103 |
| sonic hedgehog group medulloblastoma | 1482 | 0.0114451265802189 |
| glioblastoma | 5572 | 0.0163479214916403 |
| adult high grade glioma | 2148 | 0.0229864133773641 |
| medulloblastoma, large-cell | 6234 | 0.0299564762840136 |
| subependymal giant cell astrocytoma | 2287 | 0.0362177331752426 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 498 | 0.0 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -3.375 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.700 | 0.000 |
| glioblastoma | -1.200 | 0.016 |
| medulloblastoma, large-cell | -1.300 | 0.030 |
| adult high grade glioma | -1.100 | 0.023 |
| sonic hedgehog group medulloblastoma | 1.200 | 0.011 |
| subependymal giant cell astrocytoma | -2.149 | 0.036 |
| ovarian cancer | 1.600 | 0.002 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Zebrafish | OMA Inparanoid |
| PMID | Text |
|---|---|
| 23739915 | A single nucleotide polymorphisn in ZBTB46, rs6062314, is associated with an increased genetic risk for multiple sclerosis. |
MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQA 1 - 70 TVTHLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDE 71 - 140 LAEFEIGASSSSSTEALISAVMAGRSISPWLARRTSPANSSGDSAIASCHDGGSSYGKEDQEPKADGPDD 141 - 210 VSSQPLWPGDVGYGPLRIKEEQVSPSQYGGSELPSAKDGAVQNSFSEQSAGDAWQPTGRRKNRKNKETVR 211 - 280 HITQQVEDDSRASSPVPSFLPTSGWPFSSRDSNADLSVTEASSSDSRGERAELYAQVEEGLLGGEASYLG 281 - 350 PPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIRKKFKC 351 - 420 PYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVG 421 - 490 IRHGSRRHGVCTDCAGRGMAGPLDHGGGGGEGSPEALFPGDGPYLEDPEDPRGEAEELGEDDEGLAPEDA 491 - 560 LLADDKDEEDSPRPRSPPGGPDKDFAWLS 561 - 589 //
| PMID | Year | Title |
|---|---|---|
| 25218447 | 2014 | Uncovering global SUMOylation signaling networks in a site-specific manner. |
| 23739915 | 2013 | MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. |
| 23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21833088 | 2011 | Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. |
| 21297633 | 2011 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| 12136098 | 2002 | NotI flanking sequences: a tool for gene discovery and verification of the human genome. |
| More... |
