Tbio Leucine-rich repeat transmembrane neuronal protein 1

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Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

Comments

Property Summary

NCBI Gene PubMed Count	16
PubMed Score	15.80

PubTator Score	14.90

Knowledge Summary

Patent

No data available

TINX Plot

Disease (4)

Disease	Target Count
Schizophrenia	1160

Disease	Target Count	P-value
atypical teratoid / rhabdoid tumor	5112	3.2e-05
medulloblastoma, large-cell	6241	9.2e-04
adult high grade glioma	3801	9.6e-04
group 3 medulloblastoma	4104	1.5e-03
glioblastoma	5792	2.4e-03
astrocytic glioma	2597	5.7e-03
ependymoma	4679	2.1e-02

Disease	Target Count	Confidence
Carcinoma	11493	1.1
Kidney cancer	2613	0.5
Liver cancer	604	0.6

Disease	Target Count	Z-score	Confidence
Choanal Atresia	42	3.339	1.7

Differential Expression (7)

Disease	log2 FC	p
adult high grade glioma	-2.200	9.6e-04
astrocytic glioma	-1.300	5.7e-03
atypical teratoid / rhabdoid tumor	-2.600	3.2e-05
ependymoma	-1.300	2.1e-02
glioblastoma	-1.500	2.4e-03
group 3 medulloblastoma	-2.800	1.5e-03
medulloblastoma, large-cell	-2.800	9.2e-04

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Caudate (basal ganglia) 18,001

Brain - Frontal Cortex (BA9) 18,069

Brain - Cortex 18,039

Nerve - Tibial 18,007

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Hippocampus 18,011

Brain - Hypothalamus 18,169

Brain - Putamen (basal ganglia) 17,863

Colon - Sigmoid 18,089

Esophagus - Muscularis 18,017

Brain - Amygdala 18,006

Esophagus - Gastroesophageal Junction 18,000

Brain - Spinal cord (cervical c-1) 17,973

Pituitary 18,147

Brain - Substantia nigra 17,981

Vagina 17,834

Prostate 18,213

Heart - Atrial Appendage 17,896

Thyroid 18,024

Brain - Cerebellum 17,983

Colon - Transverse 17,825

Artery - Coronary 17,949

Stomach 17,879

Brain - Cerebellar Hemisphere 18,015

Adipose - Visceral (Omentum) 17,937

Testis 18,518

Uterus 17,618

Esophagus - Mucosa 18,076

Minor Salivary Gland 18,005

Small Intestine - Terminal Ileum 17,954

Skin - Sun Exposed (Lower leg) 17,968

Skin - Not Sun Exposed (Suprapubic) 18,081

Ovary 17,971

Breast - Mammary Tissue 18,103

Kidney - Cortex 17,329

Adipose - Subcutaneous 18,110

Liver 18,071

Heart - Left Ventricle 18,006

Artery - Tibial 17,631

Adrenal Gland 18,071

Artery - Aorta 17,896

Pancreas 18,123

Lung 18,057

Cells - Transformed fibroblasts 17,577

Muscle - Skeletal 17,778

Cells - EBV-transformed lymphocytes 18,186

Spleen 17,614

Whole Blood 17,439

Fetal Ovary 9,118

Adult Frontal Cortex 9,048

Adult Ovary 10,192

Frontal lobe

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

lung 16,312

ovary 15,408

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skin 16,206

small intestine 16,154

smooth muscle 15,857

stomach 16,099

testis 17,936

thyroid gland 15,959

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

See source...

Auditory vesicle 24

See source...

Synonym

Accession	Q86UE6 A8K397 D6W5K1 Q96DN1
Symbols

Gene

LRRTM1

PANTHER Protein Class (1)

extracellular matrix protein 175

Ortholog (13)

Species	Source	Disease
Rat 15,117	Inparanoid OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid EggNOG
Pig 10,168	OMA EggNOG
Chicken 7,827	Inparanoid OMA EggNOG
Platypus 5,703	Inparanoid OMA EggNOG
Xenopus 10,468	Inparanoid OMA EggNOG
Anole lizard 10,588	Inparanoid OMA
Zebrafish 9,726	Inparanoid OMA
Macaque 12,761	Inparanoid OMA EggNOG
Chimp 14,140	OMA EggNOG

UniProt Keyword (14)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Repeat 4,916

Cell membrane 3,390

Glycoprotein 4,623

Membrane 7,361

Transmembrane 5,228

Transmembrane helix 5,207

Leucine-rich repeat 312

See all...

GO Function (1)

protein kinase inhibitor activity 60

GO Component (7)

integral component of membrane 3,665

endoplasmic reticulum 938

growth cone 116

postsynaptic membrane 210

cell junction 502

axon 250

excitatory synapse 26

GO Process (10)

negative regulation of protein kinase ac... 96

cytokine-mediated signaling pathway 105

locomotory behavior 82

long-term synaptic potentiation 41

positive regulation of synapse assembly 65

negative regulation of JAK-STAT cascade 44

exploration behavior 14

negative regulation of receptor internal... 7

protein localization to synapse 13

synapse organization 35

Compartment GO Term (34)

Axon 294

Cell 16,178

Cell junction 960

Cell part 16,177

Cell periphery 5,382

Cell projection 1,541

Cell projection part 850

Cytoplasm 10,983

Cytoplasmic part 9,247

Endomembrane system 4,237

Endoplasmic reticulum 2,001

Growth cone 140

Integral component of membrane 5,331

Intracellular 14,109

Intracellular membrane-bounded organelle 10,341

See all...

MGI Phenotype (4)

homeostasis-metabolism phenotype 4,747

nervous system phenotype 3,447

behavior-neurological phenotype 3,401

normal phenotype 1,999

HCA RNA Cell Line (14)

AF22 16,160

CAPAN-2 16,102

HEK 293 15,853

K-562 16,233

Karpas-707 16,275

NTERA-2 17,039

RPTEC TERT1 15,278

RT4 15,683

SH-SY5Y 16,707

U-138 MG 15,914

See all...

Pathway (3)

Neuronal System 367

Protein-protein interactions at synapses 90

Neurexins and neuroligins 59

Protein-protein Interaction (38)

TYW1 ATP2A3 ATP13A1 LRP11 STIM1 AREL1 CLSTN1 PDE3B CNPY3 RETSAT PNPLA6 SPTLC2 TTC17 MARC1 RAB12 SUN1 TMEM131 PDZD8 NSUN3 FRAS1 TUBB8 SMPD2 NUS1 UPK3BL2 NOCT CISD2 KIAA0319L NDC1 UBE4A TMEM39A TMEM223 AMIGO1 OSBP TSPAN6 PIGA C1orf43 PCNX3 LRFN3

Gene RIF (11)

AA Sequence

MDFLLLGLCLYWLLRRPSGVVLCLLGACFQMLPAAPSGCPQLCRCEGRLLYCEALNLTEAPHNLSGLLGL      1 - 70
SLRYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLR     71 - 140
SVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFK    141 - 210
LTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVP    211 - 280
HLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQG    281 - 350
EDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTFEPATVALPGGEHAE    351 - 420
NAVQIHKVVTGTMALIFSFLIVVLVLYVSWKCFPASLRQLRQCFVTQRRKQKQKQTMHQMAAMSAQEYYV    421 - 490
DYKPNHIEGALVIINEYGSCTCHQQPARECEV                                          491 - 522
//

Text Mined References (16)

Summary
Details

	PMID	Year	Title

Tbio Leucine-rich repeat transmembrane neuronal protein 1 Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (4)

Expression

Differential Expression (7)

Synonym

Gene

PANTHER Protein Class (1)

Ortholog (13)

UniProt Keyword (14)

GO Function (1)

GO Component (7)

GO Process (10)

Compartment GO Term (34)

MGI Phenotype (4)

HCA RNA Cell Line (14)

Pathway (3)

Protein-protein Interaction (38)

Gene RIF (11)

AA Sequence

Text Mined References (16)

Tbio Leucine-rich repeat transmembrane neuronal protein 1

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