Tbio MARCH3 E3 ubiquitin-protein ligase MARCH3

Protein Summary

Description

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• Q86UD3
• A8K264
• B9EJE7

Gene Name

• MARCH3

Ensembl ID

• ENST00000308660
• ENSP00000309141
• ENSG00000173926
• ENST00000515241
• ENSP00000421979

Symbol

• RNF173
• RNF173
• MARCH-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.77
histone modification site profile	0.76
transcription factor perturbation	0.74
virus perturbation	0.64
microRNA	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.43   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.43   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0