| Tbio | RPA-interacting protein |
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.4e-11 |
| osteosarcoma | 7950 | 5.1e-08 |
| Pick disease | 1894 | 1.3e-05 |
| psoriasis | 6694 | 2.5e-05 |
| cystic fibrosis | 1696 | 2.9e-04 |
| pituitary cancer | 1972 | 6.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-03 |
| ependymoma | 4679 | 2.4e-03 |
| oligodendroglioma | 2850 | 3.6e-03 |
| lung cancer | 4740 | 3.8e-03 |
| astrocytic glioma | 2597 | 4.3e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.2e-03 |
| primitive neuroectodermal tumor | 3035 | 5.8e-03 |
| progressive supranuclear palsy | 676 | 1.7e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.3e-02 |
| group 3 medulloblastoma | 4104 | 2.7e-02 |
| Breast cancer | 3578 | 3.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.600 | 4.3e-03 |
| Breast cancer | 2.000 | 3.8e-02 |
| cystic fibrosis | -1.229 | 2.9e-04 |
| ependymoma | 2.100 | 2.4e-03 |
| group 3 medulloblastoma | 1.300 | 2.7e-02 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 2.0e-03 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 5.2e-03 |
| lung cancer | 1.800 | 3.8e-03 |
| oligodendroglioma | 1.800 | 3.6e-03 |
| osteosarcoma | -2.731 | 5.1e-08 |
| ovarian cancer | -2.100 | 1.4e-11 |
| pancreatic ductal adenocarcinoma liver m... | -1.004 | 2.3e-02 |
| Pick disease | -1.400 | 1.3e-05 |
| pituitary cancer | -1.300 | 6.5e-04 |
| primitive neuroectodermal tumor | 1.300 | 5.8e-03 |
| progressive supranuclear palsy | -1.200 | 1.7e-02 |
| psoriasis | -3.600 | 2.5e-05 |
