Tbio | RPA-interacting protein |
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 1.56435481760093E-13 |
ovarian cancer | 8492 | 1.43848739305584E-11 |
Pick disease | 1893 | 1.27518684670839E-5 |
psoriasis | 6685 | 2.46860243374676E-5 |
lung cancer | 4473 | 5.76844197553932E-5 |
cystic fibrosis | 1670 | 2.89115383065497E-4 |
pituitary cancer | 1972 | 6.52601582226888E-4 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.0019603302026914 |
ependymoma | 2514 | 0.00235065382865408 |
oligodendroglioma | 2849 | 0.00295039159151606 |
astrocytic glioma | 2241 | 0.00323028821322094 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00519115731955289 |
primitive neuroectodermal tumor | 3031 | 0.0057810675571995 |
progressive supranuclear palsy | 674 | 0.0169258947701234 |
pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.022507050952297 |
group 3 medulloblastoma | 2254 | 0.0274904027060037 |
Breast cancer | 3099 | 0.0382297880111965 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | 1.900 | 0.003 |
ependymoma | 2.100 | 0.002 |
oligodendroglioma | 2.100 | 0.003 |
psoriasis | -3.600 | 0.000 |
osteosarcoma | -4.634 | 0.000 |
cystic fibrosis | -1.229 | 0.000 |
primitive neuroectodermal tumor | 1.300 | 0.006 |
pancreatic ductal adenocarcinoma liver m... | -1.004 | 0.023 |
intraductal papillary-mucinous adenoma (... | 1.300 | 0.002 |
intraductal papillary-mucinous carcinoma... | 1.700 | 0.005 |
lung cancer | 2.400 | 0.000 |
Breast cancer | 2.000 | 0.038 |
group 3 medulloblastoma | 1.300 | 0.027 |
Pick disease | -1.400 | 0.000 |
progressive supranuclear palsy | -1.200 | 0.017 |
ovarian cancer | -2.100 | 0.000 |
pituitary cancer | -1.300 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
23010595 | hRIPalpha is involved in cell proliferation through regulation of RPA transport |
21360055 | The results show that DDX3, eIF5A, and hRIP enhance HIV-1 internal ribosomal entry site-mediated translation. |
20237496 | Observational study of gene-disease association. (HuGE Navigator) |
19336370 | Observational study of gene-disease association. (HuGE Navigator) |
16135809 | hRIPbeta localises to the PML nuclear body and transports replication protein A (PML) into the PML nuclear body and releases RPA upon UV irradiation. |
PMID | Year | Title |
---|---|---|
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
23010595 | 2012 | Elevated level of human RPA interacting protein ? (hRIP?) in cervical tumor cells is involved in cell proliferation through regulating RPA transport. |
21360055 | 2011 | Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3. |
20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. |
19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
19336370 | 2009 | Determination of genetic predisposition to patent ductus arteriosus in preterm infants. |
18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
16625196 | 2006 | DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
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