| Tbio | RPA-interacting protein |
Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Comments
Property Summary
| NCBI Gene PubMed Count | 13 |
| Grant Count | 8 |
| R01 Count | 3 |
| Funding | $928,324.25 |
| PubMed Score | 22.11 |
| PubTator Score | 16.75 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.900 | 0.003 |
| ependymoma | 2.100 | 0.002 |
| oligodendroglioma | 2.100 | 0.003 |
| psoriasis | -3.600 | 0.000 |
| osteosarcoma | -4.634 | 0.000 |
| cystic fibrosis | -1.229 | 0.000 |
| primitive neuroectodermal tumor | 1.300 | 0.006 |
| pancreatic ductal adenocarcinoma liver m... | -1.004 | 0.023 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 0.002 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 0.005 |
| lung cancer | 2.400 | 0.000 |
| Breast cancer | 2.000 | 0.038 |
| group 3 medulloblastoma | 1.300 | 0.027 |
| Pick disease | -1.400 | 0.000 |
| progressive supranuclear palsy | -1.200 | 0.017 |
| ovarian cancer | -2.100 | 0.000 |
| pituitary cancer | -1.300 | 0.001 |
| PMID | Text |
|---|---|
| 23010595 | hRIPalpha is involved in cell proliferation through regulation of RPA transport |
| 21360055 | The results show that DDX3, eIF5A, and hRIP enhance HIV-1 internal ribosomal entry site-mediated translation. |
| 20237496 | Observational study of gene-disease association. (HuGE Navigator) |
| 19336370 | Observational study of gene-disease association. (HuGE Navigator) |
| 16135809 | hRIPbeta localises to the PML nuclear body and transports replication protein A (PML) into the PML nuclear body and releases RPA upon UV irradiation. |
| PMID | Year | Title |
|---|---|---|
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 23010595 | 2012 | Elevated level of human RPA interacting protein ? (hRIP?) in cervical tumor cells is involved in cell proliferation through regulating RPA transport. |
| 21360055 | 2011 | Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3. |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 19336370 | 2009 | Determination of genetic predisposition to patent ductus arteriosus in preterm infants. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
| 16625196 | 2006 | DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| More... |
