Property Summary

NCBI Gene PubMed Count 8
PubMed Score 2.17
PubTator Score 2.83

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
astrocytoma 1493 1.88244769214764E-22
oligodendroglioma 2849 7.5689030952756E-18
posterior fossa group B ependymoma 1530 1.03751356856882E-9
lung adenocarcinoma 2714 1.46376141329168E-9
atypical teratoid / rhabdoid tumor 4369 1.92083588994649E-7
medulloblastoma 1524 2.53564651534796E-7
glioblastoma 5572 4.31520296107163E-7
pilocytic astrocytoma 3086 2.55985942063986E-6
primitive neuroectodermal tumor 3031 5.26693955100074E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 3.21732977917286E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.55044662419397E-4
osteosarcoma 7933 3.41157144825464E-4
adult high grade glioma 2148 3.71562605645181E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0014975951451488
pancreatic cancer 2300 0.00322569620440786
pancreatic carcinoma 567 0.00322569620440788
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00450142104365526
invasive ductal carcinoma 2950 0.0105711190020397
ductal carcinoma in situ 1745 0.0106771635120737
subependymal giant cell astrocytoma 2287 0.0166273149849884

Expression

Synonym

Accession Q86TV6 Q86U24 Q86VT3 TPR repeat protein 7B
Symbols TTC7L1
c14_5685

Gene

PANTHER Protein Class (2)

PDB

5DSE  

  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (1)

PMID Text
22453632 associated with IS risk in the Spanish and combined data sets. Multiple independent lines of evidence therefore support the role of TTC7B in stroke susceptibility

AA Sequence

MATKKAGSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGASPRG      1 - 70
PKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPPYRLRV     71 - 140
IAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLYLQEIERVILSNIQNRSPKPGPAPH    141 - 210
DQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELLRAVETRTTQNLRMTIARQLAEILLRGMCEQSYWN    211 - 280
PLEDPPCQSPLDDPLRKGANTKTYTLTRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPE    281 - 350
HKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVL    351 - 420
KECIRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLR    421 - 490
GMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLS    491 - 560
AQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGRGSS    561 - 630
LLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWL    631 - 700
HAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRL    701 - 770
ALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIP    771 - 840
RVL                                                                       841 - 843
//

Text Mined References (15)

PMID Year Title
26571211 2016 The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.
25608530 2015 Plasticity of PI4KIII? interactions at the plasma membrane.
25390645 2014 Genome-wide and gene-based association studies of anxiety disorders in European and African American samples.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23229899 2012 PtdIns4P synthesis by PI4KIII? at the plasma membrane and its impact on plasma membrane identity.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22453632 2012 TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches.
21993531 2012 Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
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