Tchem PRUNE1 Exopolyphosphatase PRUNE1

Protein Summary

Description

Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q86TP1
• B2RCH8
• B4DFL7
• Q5SZF9
• Q659E5
• Q6P4E0
• Q8N654
• Q96JU5
• Q9C071
• Q9C072
• Q9UIV0

Gene Name

• PRUNE1

Ensembl ID

• ENST00000271620
• ENSP00000271620
• ENSG00000143363
• ENST00000368934
• ENSP00000357930
• ENST00000368935
• ENSP00000357931
• ENST00000368936
• ENSP00000357932
• ENST00000368937
• ENSP00000357933

Symbol

• PRUNE
• PRUNE
• DRES17
• HTCD37
• NMIHBA
• DRES-17
• H-PRUNE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.53   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.53   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1