Tbio | Store-operated calcium entry regulator STIMATE |
Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Ascaridiasis | 2 | 5.621 | 2.8 |
Von Willebrand's disease | 19 | 4.573 | 2.3 |
PMID | Text |
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26644574 | Research on calcium signaling has centered on STIM1, ORAI1, and proteins that modulate their function. TMEM110 regulates the maintenance of ER-plasma membrane junctions and the short-term remodeling of junctions during store-dependent calcium signaling. |
26322679 | Data show that transmembrane protein 110 STIMATE is an endoplasmic reticulum (ER)-resident protein that co-localizes with membrane protein STIM1. |
MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIW 1 - 70 FLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFG 71 - 140 EYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMF 141 - 210 WVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPL 211 - 280 KPVKKKKHRFGLPV 281 - 294 //
PMID | Year | Title |
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26644574 | 2015 | TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling. |
26322679 | 2015 | Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²? influx. |
25056061 | 2014 | Biological insights from 108 schizophrenia-associated genetic loci. |
23974872 | 2013 | Genome-wide association analysis identifies 13 new risk loci for schizophrenia. |
22610502 | 2012 | Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. |
21926972 | 2011 | Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. |
16641997 | 2006 | The DNA sequence, annotation and analysis of human chromosome 3. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
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