You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PATL1
Protein PAT1 homolog 1

Protein Summary
Description
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300146
  • ENSP00000300146
  • ENSG00000166889

Symbol
  • Pat1b
  • hPat1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.96
virus perturbation
0.92
histone modification site profile
0.89
transcription factor binding site profile
0.78
transcription factor
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.11   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.11   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0