Tbio ADGRG6 Adhesion G-protein coupled receptor G6

Protein Summary

Description

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q86SQ4
• Q5TGN7
• Q6DHZ4
• Q6F3F5
• Q6F3F6
• Q6F3F7
• Q6F3F8
• Q6MZU7
• Q8IXA4
• Q8NC14
• Q96JW0

Gene Name

• ADGRG6

Ensembl ID

• ENST00000230173
• ENSP00000230173
• ENSG00000112414
• ENST00000296932
• ENSP00000296932
• ENST00000367608
• ENSP00000356580
• ENST00000367609
• ENSP00000356581

Symbol

• DREG
• GPR126
• VIGR
• APG1
• DREG
• VIGR
• LCCS9
• PR126
• GPR126
• PS1TP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
PubMedID	0.92
transcription factor perturbation	0.91
histone modification site profile	0.78
transcription factor binding site profile	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adhesion G-protein Coupled Receptor G6

Protein / Defense/immunity Protein / Antibacterial Response Protein / Adhesion G-protein Coupled Receptor G6

Protein / ... / Protease / Adhesion G-protein Coupled Receptor G6

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / G-protein Coupled Receptor 126

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.81   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.81   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0