Property Summary

NCBI Gene PubMed Count 15
PubMed Score 276.26
PubTator Score 86.85

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 5.76891553104134E-14
Breast cancer 3099 2.1381174367689E-7
cystic fibrosis 1670 5.11487002024576E-7
lung adenocarcinoma 2714 1.07858345961993E-6
medulloblastoma, large-cell 6234 4.19545851382622E-6
ovarian cancer 8492 9.14316443859944E-6
posterior fossa group A ependymoma 1511 4.79557342757589E-5
group 4 medulloblastoma 1875 4.8081847500396E-5
atypical teratoid / rhabdoid tumor 4369 1.03789599321461E-4
Pick disease 1893 1.3367224794251E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.92932139467948E-4
Multiple myeloma 1328 7.8098536296911E-4
pilocytic astrocytoma 3086 0.00102242941231778
subependymal giant cell astrocytoma 2287 0.00114793976059595
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00121031354374259
osteosarcoma 7933 0.0017332866915941
oligodendroglioma 2849 0.00197513474207865
tuberculosis 1563 0.00207292286649029
glioblastoma 5572 0.00208022894248213
pancreatic cancer 2300 0.00224516190664668
nasopharyngeal carcinoma 1056 0.00794078973211279
adult high grade glioma 2148 0.00819699765681534
Waldenstrons macroglobulinemia 765 0.0160527573245412
progressive supranuclear palsy 674 0.0203423359882213
Alzheimer's disease 644 0.0258343091302144
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0357345296811337
astrocytic glioma 2241 0.0453377678463641
aldosterone-producing adenoma 664 0.0462676213243805



Accession Q86SK9 B2RPG0 Q4W5Q5 Q8NDS0 Q9H7D1
Symbols SCD2


  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Dog OMA Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid
Xenopus EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
S.cerevisiae EggNOG Inparanoid

Gene RIF (10)

25802234 SCD5 appears to functionally connect tumour cells and the surrounding stroma toward modification of the tumour microenvironment, with consequences on tumour spread and resistance to treatment.
23867797 The protective effect of TO901317 was lost after gene silencing of Scd-1/-2, thereby confirming that the protective effect of TO901317 is mediated by Scd-1/-2.
22745828 Data suggest that, by a coordinated modulation of key lipogenic pathways and transduction signaling cascades, SCD5 participates in the regulation of neuronal cell growth and differentiation.
20634891 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
17468887 In this paper, we describe for the first time a second SCD isoform in cattle, which appears to be an ortholog of human SCD5 rather than a homolog of bovine SCD1 or any of the described murine SCD isoforms
15610069 The identification and characterization of SCD2, and its relationship to human SCD1 and mouse SCD2, are reported.
12815040 SCD4 demonstrates tissue-specific regulation by leptin and dietary factors

AA Sequence


Text Mined References (20)

PMID Year Title
25802234 2015 SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
23867797 2013 Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22745828 2012 StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation.
22046234 2011 Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
20634891 2010 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.