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Tbio
MEGF8
Multiple epidermal growth factor-like domains protein 8

Protein Summary
Description
Acts as a negative regulator of hedgehog signaling. The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251268
  • ENSP00000251268
  • ENSG00000105429
  • ENST00000334370
  • ENSP00000334219

Symbol
  • C19orf49
  • EGFL4
  • KIAA0817
  • SBP1
  • CRPT2
  • EGFL4
  • C19orf49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.84
histone modification site profile
0.73
cell line
0.72
gene perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0