Tdark LHFPL4 LHFPL tetraspan subfamily member 4 protein

Protein Summary

Description

Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q7Z7J7
• A6NH76
• Q29RV7

Gene Name

• LHFPL4

Ensembl ID

• ENST00000287585
• ENSP00000287585
• ENSG00000156959

Symbol

• GARLH4
• GARLH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.77
tissue	0.62
microRNA	0.6
cell line	0.5
chemical	0.44

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.27   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.27   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0