Tbio TFAP2D Transcription factor AP-2-delta

Protein Summary

Description

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).

Uniprot Accession IDs

• Q7Z6R9
• Q8IWX0
• AP2-delta

Gene Name

• TFAP2D

Ensembl ID

• ENST00000008391
• ENSP00000008391
• ENSG00000008197

Symbol

• TFAP2BL1
• TFAP2BL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
cell line	0.64
biological process	0.63
molecular function	0.56
virus perturbation	0.5

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Ap-2-delta

DTO Classes

Protein / Transcription Factor / Transcription Factor Ap-2-delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0