Tdark THAP5 THAP domain-containing protein 5

Protein Summary

Description

Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).

Uniprot Accession IDs

• Q7Z6K1

Gene Name

• THAP5

Ensembl ID

• ENST00000313516
• ENSP00000322440
• ENSG00000177683
• ENST00000415914
• ENSP00000400500

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
microRNA	0.65
tissue sample	0.54
transcription factor binding site profile	0.51
transcription factor	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0