| Tbio | SLIT-ROBO Rho GTPase-activating protein 1 |
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
Comments
| Disease | Target Count |
|---|---|
| Epithelial ovarian cancer | 19 |
| Follicular thyroid carcinoma | 11 |
| Disease | Target Count |
|---|---|
| Thyroid Cancer, Nonmedullary, 2 | 6 |
| Disease | Target Count |
|---|---|
| Thyroid cancer, non-medullary, 2 | 4 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.600 | 0.002 |
| ependymoma | 1.900 | 0.005 |
| oligodendroglioma | 1.500 | 0.004 |
| glioblastoma | 2.300 | 0.000 |
| osteosarcoma | 3.486 | 0.000 |
| atypical teratoid / rhabdoid tumor | 2.500 | 0.001 |
| sonic hedgehog group medulloblastoma | 1.500 | 0.001 |
| medulloblastoma, large-cell | 1.500 | 0.000 |
| primitive neuroectodermal tumor | 1.600 | 0.008 |
| tuberculosis and treatment for 3 months | -1.400 | 0.000 |
| intraductal papillary-mucinous adenoma (... | 2.000 | 0.000 |
| intraductal papillary-mucinous carcinoma... | 2.100 | 0.000 |
| intraductal papillary-mucinous neoplasm ... | 1.600 | 0.001 |
| pediatric high grade glioma | 1.600 | 0.000 |
| pilocytic astrocytoma | 1.300 | 0.000 |
| primary Sjogren syndrome | -1.300 | 0.000 |
| subependymal giant cell astrocytoma | 1.685 | 0.048 |
| psoriasis | -1.100 | 0.000 |
| Alzheimer's disease | 1.200 | 0.016 |
| Pick disease | 2.200 | 0.000 |
| gastric carcinoma | 1.500 | 0.049 |
| mucosa-associated lymphoid tissue lympho... | 1.423 | 0.039 |
| ovarian cancer | -1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Pig | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| Xenopus | OMA Inparanoid |
| PMID | Text |
|---|---|
| 26026792 | Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract |
| 26026080 | The elevated miR-145 present in invasive glioblastoma cells (IM3 cells) targets and down-regulated srGAP1, thereby allowing downstream G-proteins to remain in their active state and promote the observed invasive phenotype |
| 25150978 | The interaction of betaPix with srGAP1 is critical for maintaining suppressive crosstalk between Cdc42 and RhoA during 3D collagen migration. |
| 25134534 | we identified a consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 x 10(-7)) |
| 24006490 | Data indicate that srGAP1 possesses a GAP activity specific to Rac1 and is recruited to lamellipodia in a Rac1-dependent manner. |
| 23539728 | genome-wide linkage analysis in populations in Ohio and Poland: Data suggest that missense mutations in SRGAP1 are associated with genetic predisposition to papillary thyroid carcinoma. |
| 21060114 | This study proposed that the expression of SRGAP1 in the anterior neocortex may mark the early location of the human motor cortex, including its corticospinal projection neurons, allowing further study of their early differentiation. |
| 20237496 | Observational study of gene-disease association. (HuGE Navigator) |
| 12736724 | FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. |
MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKL 1 - 70 AERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMF 71 - 140 KKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQ 141 - 210 RRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRA 211 - 280 LRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQP 281 - 350 VQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL 351 - 420 SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKH 421 - 490 RKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERG 491 - 560 ENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIV 561 - 630 MRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKEL 631 - 700 DGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASL 701 - 770 LLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH 771 - 840 PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERR 841 - 910 RRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQS 911 - 980 TAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQL 981 - 1050 KPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM 1051 - 1085 //
| PMID | Year | Title |
|---|---|---|
| 26026792 | 2015 | Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract. |
| 26026080 | 2015 | MicroRNA-145 Promotes the Phenotype of Human Glioblastoma Cells Selected for Invasion. |
| 25150978 | 2014 | An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration. |
| 25134534 | 2014 | Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. |
| 24006490 | 2013 | srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity. |
| 23539728 | 2013 | SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22467852 | 2012 | The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 21060114 | 2011 | The corticofugal neuron-associated genes ROBO1, SRGAP1, and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development. |
| More... |
