| Tbio | SLIT-ROBO Rho GTPase-activating protein 1 |
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Thyroid cancer, follicular | 8 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 6.3e-09 |
| osteosarcoma | 7950 | 9.0e-06 |
| Pick disease | 1894 | 1.4e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.4e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.1e-05 |
| glioblastoma | 5792 | 2.1e-04 |
| tuberculosis | 2010 | 3.5e-04 |
| ovarian cancer | 8520 | 4.6e-04 |
| adult high grade glioma | 3801 | 5.1e-04 |
| Astrocytoma, Pilocytic | 3081 | 5.5e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 9.0e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.4e-03 |
| astrocytic glioma | 2597 | 2.1e-03 |
| medulloblastoma, large-cell | 6241 | 3.5e-03 |
| oligodendroglioma | 2850 | 4.4e-03 |
| primitive neuroectodermal tumor | 3035 | 8.4e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.4e-02 |
| Alzheimer's disease | 658 | 1.6e-02 |
| group 4 medulloblastoma | 1855 | 2.3e-02 |
| ependymoma | 4679 | 2.5e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 3.9e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.8e-02 |
| gastric carcinoma | 807 | 4.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Familial hypocalciuric hypercalcemia | 20 | 4.099 | 2.0 |
| Carney complex | 25 | 3.342 | 1.7 |
| Disease | Target Count |
|---|---|
| Thyroid Cancer, Nonmedullary, 2 | 6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.600 | 5.1e-04 |
| Alzheimer's disease | 1.200 | 1.6e-02 |
| astrocytic glioma | 1.600 | 2.1e-03 |
| Astrocytoma, Pilocytic | 1.300 | 5.5e-04 |
| atypical teratoid / rhabdoid tumor | 2.500 | 1.4e-03 |
| ependymoma | 1.400 | 2.5e-02 |
| gastric carcinoma | 1.500 | 4.9e-02 |
| glioblastoma | 1.100 | 2.1e-04 |
| group 4 medulloblastoma | -1.100 | 2.3e-02 |
| intraductal papillary-mucinous adenoma (... | 2.000 | 3.1e-05 |
| intraductal papillary-mucinous carcinoma... | 2.100 | 2.4e-05 |
| intraductal papillary-mucinous neoplasm ... | 1.600 | 9.0e-04 |
| medulloblastoma, large-cell | 1.400 | 3.5e-03 |
| mucosa-associated lymphoid tissue lympho... | 1.423 | 3.9e-02 |
| non primary Sjogren syndrome sicca | -1.200 | 1.4e-02 |
| oligodendroglioma | 1.500 | 4.4e-03 |
| osteosarcoma | 2.214 | 9.0e-06 |
| ovarian cancer | -1.100 | 4.6e-04 |
| Pick disease | 2.200 | 1.4e-05 |
| primitive neuroectodermal tumor | 1.600 | 8.4e-03 |
| psoriasis | -1.100 | 6.3e-09 |
| subependymal giant cell astrocytoma | 1.685 | 4.8e-02 |
| tuberculosis | -1.300 | 3.5e-04 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKL 1 - 70 AERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMF 71 - 140 KKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQ 141 - 210 RRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRA 211 - 280 LRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQP 281 - 350 VQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL 351 - 420 SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKH 421 - 490 RKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERG 491 - 560 ENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIV 561 - 630 MRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKEL 631 - 700 DGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASL 701 - 770 LLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH 771 - 840 PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERR 841 - 910 RRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQS 911 - 980 TAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQL 981 - 1050 KPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM 1051 - 1085 //
