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Tbio
AKNA
AT-hook-containing transcription factor

Protein Summary
Description
Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223791
  • ENSP00000223791
  • ENSG00000106948
  • ENST00000307564
  • ENSP00000303769
  • ENST00000312033
  • ENSP00000309222
  • ENST00000374075
  • ENSP00000363188
  • ENST00000374079
  • ENSP00000363192
  • ENST00000374088
  • ENSP00000363201

Symbol
  • KIAA1968
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
tissue sample
0.72
gene perturbation
0.62
cell line
0.56
microRNA
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.56   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.56   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0