| Tdark | Prolyl 4-hydroxylase subunit alpha-3 |
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2714 | 3.76543995455428E-6 |
| invasive ductal carcinoma | 2950 | 1.15260046234023E-5 |
| ovarian cancer | 8492 | 1.15793613687005E-5 |
| X-linked cerebral adrenoleukodystrophy | 115 | 0.00103963068766431 |
| interstitial cystitis | 2299 | 0.00105296938406352 |
| non-inflammatory breast cancer | 208 | 0.00938804503991212 |
| glioblastoma | 5572 | 0.0128373869248741 |
| osteosarcoma | 7933 | 0.0134161435604007 |
| fibroadenoma | 557 | 0.0177792071520819 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Renal clear cell carcinoma | 5 | 3.423 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.372 | 0.013 |
| glioblastoma | 1.200 | 0.013 |
| X-linked cerebral adrenoleukodystrophy | 1.400 | 0.001 |
| fibroadenoma | 1.400 | 0.018 |
| interstitial cystitis | 1.800 | 0.001 |
| lung adenocarcinoma | 1.400 | 0.000 |
| invasive ductal carcinoma | 1.352 | 0.000 |
| non-inflammatory breast cancer | 1.300 | 0.009 |
| ovarian cancer | -1.100 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYD 1 - 70 KVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDLEGAARAL 71 - 140 MRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSL 141 - 210 FRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLLAESPNH 211 - 280 VVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIAL 281 - 350 YHDFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRP 351 - 420 PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRN 421 - 490 AALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED 491 - 544 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16885164 | 2006 | The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 14500733 | 2003 | Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. |
| 12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |
| 12874193 | 2003 | Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque. |
| More... |
