| Tdark | Prolyl 4-hydroxylase subunit alpha-3 |
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 3.8e-06 |
| invasive ductal carcinoma | 2951 | 1.2e-05 |
| ovarian cancer | 8520 | 1.2e-05 |
| X-linked cerebral adrenoleukodystrophy | 116 | 1.0e-03 |
| interstitial cystitis | 2312 | 1.1e-03 |
| inflammatory breast cancer | 286 | 8.5e-03 |
| glioblastoma | 5792 | 1.3e-02 |
| osteosarcoma | 7950 | 1.3e-02 |
| fibroadenoma | 559 | 1.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Renal clear cell carcinoma | 6 | 3.322 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| fibroadenoma | 1.400 | 1.8e-02 |
| glioblastoma | 1.200 | 1.3e-02 |
| inflammatory breast cancer | 1.200 | 8.5e-03 |
| interstitial cystitis | 1.800 | 1.1e-03 |
| invasive ductal carcinoma | 1.352 | 1.2e-05 |
| lung adenocarcinoma | 1.400 | 3.8e-06 |
| osteosarcoma | 1.372 | 1.3e-02 |
| ovarian cancer | -1.100 | 1.2e-05 |
| X-linked cerebral adrenoleukodystrophy | 1.400 | 1.0e-03 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA |
NFATC2IP
HSPA5
ZNF592
UBR5
RBM15B
P4HB
ZNF579
SRCAP
DMAP1
FXR2
RSRC2
SCRIB
VPS72
KIF21A
ZMYND8
PATZ1
TSC2
YLPM1
ZNF687
TRPS1
PEX14
SRRM1
FAM120C
ZBTB7B
SF1
PWWP2A
HASPIN
ACTR6
PPHLN1
KMT2B
TP53BP2
SLBP
FBRS
ZNF318
CHAF1A
ZNF787
SESTD1
YEATS4
SIX1
NF1
FAM171A2
DISC1
AGAP1
WDR33
PWWP2B
SATB1
ZNF444
MTCL1
TIGD5
CASKIN2
PDF
BCL2L11
ZNHIT1
MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYD 1 - 70 KVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDLEGAARAL 71 - 140 MRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSL 141 - 210 FRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLLAESPNH 211 - 280 VVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIAL 281 - 350 YHDFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRP 351 - 420 PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRN 421 - 490 AALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED 491 - 544 //
