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Tdark Prolyl 4-hydroxylase subunit alpha-3

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 2.86
PubTator Score 0.50

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Renal clear cell carcinoma 6 3.322 1.7

Expression

  Differential Expression (9)

Disease log2 FC p
fibroadenoma 1.400 1.8e-02
glioblastoma 1.200 1.3e-02
inflammatory breast cancer 1.200 8.5e-03
interstitial cystitis 1.800 1.1e-03
invasive ductal carcinoma 1.352 1.2e-05
lung adenocarcinoma 1.400 3.8e-06
osteosarcoma 1.372 1.3e-02
ovarian cancer -1.100 1.2e-05
X-linked cerebral adrenoleukodystrophy 1.400 1.0e-03

Synonym

Accession Q7Z4N8 A0AV13 B4DUD3 Q5EBL3 Q5JPA9 4-PH alpha-3
Symbols

Gene

P4HA3

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Function (4)

 GO Component (1)

 Compartment GO Term (20)

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 HCA RNA Cell Line (29)

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Pathway (17)

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Protein-protein Interaction (53)

NFATC2IP   HSPA5   ZNF592   UBR5   RBM15B   P4HB   ZNF579   SRCAP   DMAP1   FXR2   RSRC2   SCRIB   VPS72   KIF21A   ZMYND8   PATZ1   TSC2   YLPM1   ZNF687   TRPS1   PEX14   SRRM1   FAM120C   ZBTB7B   SF1   PWWP2A   HASPIN   ACTR6   PPHLN1   KMT2B   TP53BP2   SLBP   FBRS   ZNF318   CHAF1A   ZNF787   SESTD1   YEATS4   SIX1   NF1   FAM171A2   DISC1   AGAP1   WDR33   PWWP2B   SATB1   ZNF444   MTCL1   TIGD5   CASKIN2   PDF   BCL2L11   ZNHIT1  

Gene RIF (3)

AA Sequence 

MGPGARLAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYD      1 - 70
KVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDLEGAARAL     71 - 140
MRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSL    141 - 210
FRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLLAESPNH    211 - 280
VVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIAL    281 - 350
YHDFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRP    351 - 420
PYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSVPVVRN    421 - 490
AALFWWNLHRSGEGDSDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPCSSSPED                    491 - 544
//

Text Mined References (12)

PMID Year Title