Property Summary

NCBI Gene PubMed Count 15
PubMed Score 1.66
PubTator Score 3.63

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 4.01972283378676E-12
pilocytic astrocytoma 3086 3.49613814224626E-8
malignant mesothelioma 3163 7.44528598165828E-8
osteosarcoma 7933 7.24629505599556E-7
nasopharyngeal carcinoma 1056 1.91926007596481E-5
pediatric high grade glioma 2712 2.23953949706372E-5
medulloblastoma, large-cell 6234 4.87790006629936E-5
ovarian cancer 8492 1.09290517856542E-4
psoriasis 6685 1.26790153239409E-4
Multiple myeloma 1328 2.75021375416435E-4
group 4 medulloblastoma 1875 0.00208472640308995
Down syndrome 548 0.0026890710435666
astrocytoma 1493 0.00288553195056705
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00302970099916482
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00435205205833883
mucosa-associated lymphoid tissue lymphoma 480 0.00813827614371501
subependymal giant cell astrocytoma 2287 0.0113937269554996
glioblastoma 5572 0.0273663651347615
spina bifida 1064 0.0345855386838441

Expression

Synonym

Accession Q7Z4F1 A8K4R5 D3DS31 O95882 Q14CK7 Q86T02 Q8NCZ4 Q9HC42 Q9UG33 LRP-10
Symbols LRP9
LRP-10
MST087
MSTP087

Gene

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG

Gene RIF (3)

PMID Text
25492683 In Mayer-Rokitansky-Kuster-Hauser syndrome in monoztgotic twins, LRP10 was identified as one of the candidate genes.
22734645 Increased expression of LRP10 in human neuroblastoma SH-SY5Y cells induces the accumulation of mature APP in the Golgi and reduces its presence at the cell surface and its processing into Abeta.
20093106 LRP10 may interfere with the formation of the beta-catenin/TCF complex and/or its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway.

AA Sequence

MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVT      1 - 70
IRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMC     71 - 140
LQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTH    141 - 210
LASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLS    211 - 280
GQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDE    281 - 350
EDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG    351 - 420
QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQ    421 - 490
QAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRL    491 - 560
RRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPA    561 - 630
PTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPG    631 - 700
VWVAEAEDEPLLT                                                             701 - 713
//

Text Mined References (20)

PMID Year Title
25492683 2015 Mayer-Rokitansky-Küster-Hauser syndrome discordance in monozygotic twins: matrix metalloproteinase 14, low-density lipoprotein receptor-related protein 10, extracellular matrix, and neoangiogenesis genes identified as candidate genes in a tissue-specific mosaicism.
22734645 2012 LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.
20093106 2010 The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19946888 2010 Defining the membrane proteome of NK cells.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16751776 2006 A germline-specific class of small RNAs binds mammalian Piwi proteins.
16341674 2005 Transcriptome analysis of human gastric cancer.
More...