Tbio ERAS GTPase ERas

Protein Summary

Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity). This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q7Z444
• E-Ras

Gene Name

• ERAS

Ensembl ID

• ENST00000338270
• ENSP00000339136
• ENSG00000187682
• ENST00000636362
• ENSP00000490793

Symbol

• HRAS2
• HRASP
• HRAS2
• HRASP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
disease	0.61
gene perturbation	0.59
protein domain	0.58
PubMedID	0.57

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Eras

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtpase Eras

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.99   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 392   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.99   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0