Tbio UBE3B Ubiquitin-protein ligase E3B

Protein Summary

Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q7Z3V4
• A5D8Z3
• Q05BX9
• Q659F7
• Q7Z7Q1
• Q9BXZ4

Gene Name

• UBE3B

Ensembl ID

• ENST00000340074
• ENSP00000342614
• ENSG00000151148
• ENST00000342494
• ENSP00000340596
• ENST00000434735
• ENSP00000391529
• ENST00000449510
• ENSP00000395802
• ENST00000536398
• ENSP00000440585
• ENST00000540230
• ENSP00000443565

Symbol

• KOS
• BPIDS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
kinase perturbation	0.84
transcription factor perturbation	0.84
tissue sample	0.77
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.22   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.22   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0