Property Summary

NCBI Gene PubMed Count 8
Grant Count 1
Funding $132,391
PubMed Score 19.30
PubTator Score 6.02

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q7RTW8 A1L3A8 A2VDI0 B3KWU3 E9PF51 Q8NA86 Q96M76
Symbols CT108
DFNB22

Gene

 Grant Application (1)

Gene RIF (3)

PMID Text
23173898 A description of two novel OTOA mutations that were discovered in three consanguineous Pakistani families segregating autosomal recessive non-syndromic hearing impairment.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19888295 Large deletions in OTOA gene is associated with hearing loss.

AA Sequence

MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQSSHVWTDDLSH      1 - 70
RVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQFRTAMKCLLEDKKDGLDLKDIII     71 - 140
DLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVEILGKVLRGSSGSFLQPDITERLPRDLREDAFK    141 - 210
NLSAVFKDLYDKTSAHSQRALYSWMTGILQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIE    211 - 280
IGLFISYDNATKQLDMVYDITPELAQAFLERISSSNFNMRNTSTIHRQAHELWALEPFPKMLGLLVCFYN    281 - 350
DLELLDATVAQVLLYQMIKCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLS    351 - 420
PEAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRS    421 - 490
AVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELGRSQALF    491 - 560
LYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSPYQVNCLAWKYWEVSRL    561 - 630
SMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMG    631 - 700
NLLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLF    701 - 770
SGDELSSIATKFPEILLQAASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKL    771 - 840
AEANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALAL    841 - 910
NESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPL    911 - 980
IKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAELRMLDKDLMPY    981 - 1050
FQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGP   1051 - 1120
TRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW                                        1121 - 1153
//

Text Mined References (10)

PMID Year Title
23173898 2013 Novel OTOA mutations cause autosomal recessive non-syndromic hearing impairment in Pakistani families.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19888295 2010 Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families.
19139490 2009 A strategy for precise and large scale identification of core fucosylated glycoproteins.
19088187 2008 Genome-wide analysis of cancer/testis gene expression.
15616553 2004 The sequence and analysis of duplication-rich human chromosome 16.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11972037 2002 Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.