Tchem TAS2R42 Taste receptor type 2 member 42

Protein Summary

Description

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

Uniprot Accession IDs

• Q7RTR8
• A2RRP4
• Q645X0
• T2R42

Gene Name

• TAS2R42

Ensembl ID

• ENST00000334266
• ENSP00000334050
• ENSG00000186136

Symbol

• TAS2R55
• T2R24
• T2R42
• T2R55
• TAS2R55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.7
cell line	0.62
cellular component	0.43
tissue	0.41
pathway	0.38

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Taste 2 Receptor / Taste Receptor Type 2 Member 42

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.38   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 24   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.38   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1