Tbio KDM3B Lysine-specific demethylase 3B

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.

Uniprot Accession IDs

• Q7LBC6
• A6H8X7
• Q9BVH6
• Q9BW93
• Q9BZ52
• Q9NYF4
• Q9UPS0

Gene Name

• KDM3B

Ensembl ID

• ENST00000314358
• ENSP00000326563
• ENSG00000120733
• ENST00000542866
• ENSP00000439462

Symbol

• C5orf7
• JHDM2B
• JMJD1B
• KIAA1082
• 5qNCA
• NET22
• C5orf7
• JMJD1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.96
disease perturbation	0.83
transcription factor binding site profile	0.81
microRNA	0.75
transcription factor	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Lysine-specific Demethylase 3b

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Jumonji Domain-containing / Lysine-specific Demethylase 3b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.88   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.88   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0