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Tbio
DPH6
Diphthine--ammonia ligase

Protein Summary
Description
Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256538
  • ENSP00000256538
  • ENSG00000134146
  • ENST00000440392
  • ENSP00000406976

Symbol
  • ATPBD4
  • ATPBD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
microRNA
0.87
molecular function
0.86
cell type or tissue
0.74
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0