Property Summary

NCBI Gene PubMed Count 11
PubMed Score 4.97
PubTator Score 4.23

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
malignant mesothelioma 3163 8.4811432941209E-8
ovarian cancer 8492 5.6916161537188E-7
psoriasis 6685 3.98868212812468E-6
ulcerative colitis 2087 4.13144615749875E-6
active Crohn's disease 918 0.00123143274862018
medulloblastoma, large-cell 6234 0.0021170452284904
osteosarcoma 7933 0.00531294028705163
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.023889076307273
oligodendroglioma 2849 0.0473173561129614

Expression

  Differential Expression (9)

Disease log2 FC p
malignant mesothelioma -2.000 0.000
oligodendroglioma -1.200 0.047
psoriasis -1.100 0.000
osteosarcoma 1.354 0.005
medulloblastoma, large-cell -1.200 0.002
intraductal papillary-mucinous carcinoma... -1.200 0.024
active Crohn's disease 2.216 0.001
ulcerative colitis 1.500 0.000
ovarian cancer -2.200 0.000

Synonym

Accession Q7L311 O60267 Q5H9D9
Symbols ALEX2
GASP9

Gene

  Ortholog (7)

Gene RIF (1)

PMID Text
22249249 Data indicate that ARMCX2, COL1A1, MDK, MEST and MLH1 genes acquired methylation in drug-resistant ovarian cancer-sustaining (side population) cells.

AA Sequence

MSRVRDAGCVAAGIVIGAGAWYCVYKYTRGRDQTKKRMAKPKNRAVAGTGARARAGLRAGFTIDLGSGFS      1 - 70
PPTPVRAEAEDRAQDEASALDTVGAEAVAPAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIA     71 - 140
PPPGVTEALGAAEAPAMAGAPKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPG    141 - 210
VASPTEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSATGAVPK    211 - 280
GGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAEVPDSEEGESGWTDTES    281 - 350
DSDSEPETQRRGRGRRPVAMQKRPFPYEIDEILGVRDLRKVLALLQKSDDPFIQQVALLTLSNNANYSCN    351 - 420
QETIRKLGGLPIIANMINKTDPHIKEKALMAMNNLSENYENQGRLQVYMNKVMDDIMASNLNSAVQVVGL    421 - 490
KFLTNMTITNDYQHLLVNSIANFFRLLSQGGGKIKVEILKILSNFAENPDMLKKLLSTQVPASFSSLYNS    491 - 560
YVESEILINALTLFEIIYDNLRAEVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLLVKVKVIKLVN    561 - 630
KF                                                                        631 - 632
//

Text Mined References (11)

PMID Year Title
22569362 2012 The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
22249249 2012 Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.
16221301 2005 Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.
15772651 2005 The DNA sequence of the human X chromosome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15383276 2004 A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11162520 2001 ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.
9628581 1998 Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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