| Tdark | Putative microRNA 17 host gene protein |
This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
Comments
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -3.028 | 0.000 |
| glioblastoma | 1.300 | 0.000 |
| sonic hedgehog group medulloblastoma | 2.400 | 0.000 |
| atypical teratoid / rhabdoid tumor | 2.000 | 0.000 |
| medulloblastoma, large-cell | 2.700 | 0.000 |
| primitive neuroectodermal tumor | 2.500 | 0.000 |
| Atopic dermatitis | 1.100 | 0.002 |
| active ulcerative colitis | -1.009 | 0.021 |
| pediatric high grade glioma | 1.100 | 0.000 |
| PMID | Text |
|---|---|
| 26837962 | MIR17HG gene expression is dysregulated in gastric cancer. |
| 26545119 | vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells |
| 26360630 | Germline heterozygous deletions of MIR17HG is associated with feingold syndrome-2. |
| 26233958 | Our findings demonstrate an important role of the miR-17-92 cluster in hepatocarcinogenesis and suggest the possibility of targeting this pivotal miRNA cluster for potential therapy. |
| 25887381 | Our findings identify the miR-17-92 cluster as a functionally determining family of miRNAs in pancreatic cancer stem cells, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs. |
| 25870038 | Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation |
| 25732734 | WEE1 is a valid target of the miR-17-92 cluster in leukemia. |
| 25634356 | The oncogenic miR-17-92 cluster is involved in cutaneous B-cell lymphoma progression. |
| 25415674 | The current results of our study support a relationship between the miR-17-92 family and lipid metabolism |
| 25359779 | STAT3 activation is related to the up-regulation of miR-17-92 clusters in retinoblastoma cells via positive feedback loop between them |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26837962 | miR-17-92 host gene, uderexpressed in gastric cancer and its expression was negatively correlated with the metastasis. | |
| 26545119 | 2015 | Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-? Signaling. |
| 26360630 | 2015 | Expanding the phenotype of feingold syndrome-2. |
| 26233958 | 2015 | MiR-17-92 cluster promotes hepatocarcinogenesis. |
| 25887381 | 2015 | The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells. |
| 25870038 | 2015 | Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation. |
| 25732734 | 2015 | WEE1 is a validated target of the microRNA miR-17-92 cluster in leukemia. |
| 25634356 | 2015 | The High Expression of the microRNA 17-92 Cluster and its Paralogs, and the Downregulation of the Target Gene PTEN, Is Associated with Primary Cutaneous B-Cell Lymphoma Progression. |
| 25415674 | 2014 | Association of plasma MiR-17-92 with dyslipidemia in patients with coronary artery disease. |
| 25359779 | 2014 | STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters. |
| More... |
