| Tdark | Putative microRNA 17 host gene protein |
This gene is the host gene for the MIR17-92 cluster, a group of at least six microRNAs (miRNAs) that may be involved in cell survival, proliferation, differentiation, and angiogenesis. Amplification of this gene has been found in several lymphomas and solid tumors. Two non-protein coding transcript variants have been found for this host gene, but only the longest is a polycistronic transcript containing the MIR17-92 cluster. [provided by RefSeq, May 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bone Diseases, Developmental | 27 | 0.0 | 0.0 |
| Coronary Disease | 25 | 0.0 | 0.0 |
| Diabetes Mellitus, Type 2 | 142 | 0.0 | 0.0 |
| Growth Disorders | 35 | 0.0 | 0.0 |
| Limb Deformities, Congenital | 16 | 0.0 | 0.0 |
| Microcephaly | 166 | 0.0 | 0.0 |
| Oculodigitoesophagoduodenal syndrome | 2 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| FEINGOLD SYNDROME 2 | 1 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 6.0e-07 |
| glioblastoma | 5792 | 7.8e-06 |
| medulloblastoma, large-cell | 6241 | 7.8e-06 |
| group 3 medulloblastoma | 4104 | 1.6e-05 |
| pediatric high grade glioma | 1064 | 1.8e-05 |
| osteosarcoma | 7950 | 3.3e-05 |
| primitive neuroectodermal tumor | 3035 | 3.4e-05 |
| Atopic dermatitis | 952 | 1.5e-03 |
| active ulcerative colitis | 764 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | -1.009 | 2.1e-02 |
| Atopic dermatitis | 1.100 | 1.5e-03 |
| atypical teratoid / rhabdoid tumor | 2.000 | 6.0e-07 |
| glioblastoma | 1.200 | 7.8e-06 |
| group 3 medulloblastoma | 1.600 | 1.6e-05 |
| medulloblastoma, large-cell | 2.700 | 7.8e-06 |
| osteosarcoma | -3.028 | 3.3e-05 |
| pediatric high grade glioma | 1.100 | 1.8e-05 |
| primitive neuroectodermal tumor | 2.500 | 3.4e-05 |
