Tbio MED25 Mediator of RNA polymerase II transcription subunit 25

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q71SY5
• A8K095
• B9TX30
• O95783
• Q6P143
• Q6QMH5
• Q707U4
• Q8TB55
• Q9H0L5
• Q9HB34

Gene Name

• MED25

Ensembl ID

• ENST00000312865
• ENSP00000326767
• ENSG00000104973
• ENST00000538643
• ENSP00000437496

Symbol

• ACID1
• ARC92
• PTOV2
• P78
• ACID1
• ARC92
• BVSYS
• PTOV2
• CMT2B2
• TCBAP0758

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.75
protein domain	0.73
transcription factor binding site profile	0.72
small molecule perturbation	0.69
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mediator Of Rna Polymerase Ii Transcription Subunit 25

DTO Classes

Protein / Transcription Factor / Mediator Of Rna Polymerase Ii Transcription Subunit 25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0