Property Summary

NCBI Gene PubMed Count 20
PubMed Score 15.17
PubTator Score 20.72

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
non-small cell lung carcinoma 413 3.33281861109617E-26
lung adenocarcinoma 2714 5.36015206647416E-17
lung carcinoma 2844 1.80462869268473E-11
medulloblastoma, large-cell 6234 6.86812297978256E-7
atypical teratoid / rhabdoid tumor 4369 4.31495942448047E-6
group 4 medulloblastoma 1875 2.09141246708505E-5
ductal carcinoma in situ 1745 6.96754196206128E-5
invasive ductal carcinoma 2950 1.50735914642937E-4
glioblastoma 5572 0.00180623834154082
pilocytic astrocytoma 3086 0.00327239978998803
primitive neuroectodermal tumor 3031 0.00655162768183131
pediatric high grade glioma 2712 0.00722338654506605
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0163361771372599
ovarian cancer 8492 0.0215034964113787
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0236434772394563
Disease Target Count Z-score Confidence
Melanoma 261 3.324 1.7
Carcinoma 2147 0.0 1.0
Skin cancer 37 0.0 1.0
Disease Target Count Z-score Confidence
Dermatitis 141 0.0 1.0
Disease Target Count
bladder exstrophy 12

Expression

Synonym

Accession Q70Z35 B4DFX0 Q32KL0 Q32KL1 Q6R7Q3 Q6R7Q4 Q9H805 Q9H961 P-Rex2
Symbols DEP.2
DEPDC2
P-REX2
PPP1R129

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (16)

PMID Text
26884185 findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator
26718453 The results of the present study suggested that PREX2a may act as an oncogene in osteosarcoma via the inhibition of PTEN activity and activation of PI3K signaling.
26438819 second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.
25829446 PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion.
25151370 CXCL9 is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2.
24375644 Results demonstrate that miR-338-3p affects gastric cancer progression through PTEN-AKT signaling by targeting P-Rex2a in gastric cancer cells
24367090 P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis
24140344 MiR-338-3p affects the PTEN/Akt pathway by down-regulating PREX2a.
23033535 Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 and Vav3 play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis.
22622578 Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN-interacting protein and negative regulator of PTEN in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas
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AA Sequence

MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETV      1 - 70
KMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIR     71 - 140
TIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSN    141 - 210
INEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHR    211 - 280
RLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKH    281 - 350
EWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLL    351 - 420
EIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLH    421 - 490
SLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLL    491 - 560
FRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGM    561 - 630
EVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVH    631 - 700
AVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQK    701 - 770
SHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMI    771 - 840
EPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRISSYKKFSRVL    841 - 910
KNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQG    911 - 980
KLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDL    981 - 1050
LSSITYSPKLERKTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIAS   1051 - 1120
FTSICSSQCSSYFHSDEMDSGDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKY   1121 - 1190
LTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQ   1191 - 1260
LRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTD   1261 - 1330
EQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGG   1331 - 1400
FKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVD   1401 - 1470
KLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSV   1471 - 1540
TLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE       1541 - 1606
//

Text Mined References (22)

PMID Year Title
26884185 2016 Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
26718453 2016 Knockdown of PREX2a inhibits the malignant phenotype of osteosarcoma cells.
26438819 2015 p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
25829446 2015 PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
25151370 2014 The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.
24375644 2014 miR-338-3p suppresses gastric cancer progression through a PTEN-AKT axis by targeting P-REX2a.
24367090 2014 Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
24140344 2013 miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a.
23033535 2012 Rho GEFs and cancer: linking gene expression and metastatic dissemination.
22622578 2012 Melanoma genome sequencing reveals frequent PREX2 mutations.
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