Tbio USP51 Ubiquitin carboxyl-terminal hydrolase 51

Protein Summary

Description

Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).

Uniprot Accession IDs

• Q70EK9
• Q8IWJ8

Gene Name

• USP51

Ensembl ID

• ENST00000500968
• ENSP00000423333
• ENSG00000247746

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
tissue	0.75
protein domain	0.73
microRNA	0.63
molecular function	0.6

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Ubiquitin Carboxyl-terminal Hydrolase 51

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ubiquitin Carboxyl-terminal Hydrolase 51

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0