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  6. Espin-like protein

Tdark Espin-like protein

Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing.

 Comments

Property Summary

NCBI Gene PubMed Count 3
PubMed Score 0.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
osteosarcoma 7950 9.6e-09
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Liver cancer 604 0.0 0.5

Expression

  Differential Expression (1)

Disease log2 FC p
osteosarcoma 1.784 9.6e-09

Synonym

Accession Q6ZVH7 Q66K27 Q6ZVG1 Q8IVU2
Symbols

Gene

ESPNL

PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 UniProt Keyword (10)

 GO Function (1)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (17)

See all...

 IMPC Phenotype (2)

 MGI Phenotype (3)

 HCA RNA Cell Line (33)

See all...

AA Sequence 

MEKQRALVAAKDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPGNQRAHNG      1 - 70
ATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARP     71 - 140
LHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLVKDCGADVHLRALDGMSALH    141 - 210
AAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAE    211 - 280
NGQMECCQTLVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATR    281 - 350
RSLEDGRRGGPGPGNPSPMSLSPAWPGHPDQPLPREQMTSPAPPRIITSATADPEGTETALAGDTSDGLA    351 - 420
ALQLDGLPSGDIDGLVPTRDERGQPIPEWKRQVMVRKLQARLGAESSAEAQDNGGSSGPTEQAAWRYSQT    421 - 490
HQAILGPFGELLTEDDLVYLEKQIADLQLRRRCQEYESELGRLAAELQALLPEPLVSITVNSHFLPRAPG    491 - 560
LEVEEASIPAAEPAGSAEASEVAPGVQPLPFWCSHISRLVRSLSLLLKGVHGLVQGDEKPSTRPLQDTCR    561 - 630
EASASPPRSEAQRQIQEWGVSVRTLRGNFESASGPLCGFNPGPCEPGAQHRQCLSGCWPALPKPRSGLAS    631 - 700
GEPRPGDTEEASDSGISCEEVPSEAGAAAGPDLASLRKERIIMLFLSHWRRSAYTPALKTVACRTLGARH    701 - 770
AGLRGQEAARSPGPPSPPSEGPRLGHLWQQRSTITHLLGNWKAIMAHVPARQLRRLSRQPRGALSPEQFL    771 - 840
PHVDGAPVPYSSLSLDLFMLGYFQLLECDLPAEERKLRHLLCFEVFEHLGTHGWEAVRAFHKAVTDEVAA    841 - 910
GRRAWTDGFEDIKARFFGSSQRPAWDTEPGRKSGLTLLGPLPHAAVPCSGPEPTAQRLGSRSQQGSFNGE    911 - 980
DICGYINRSFAFWKEKEAEMFNFGE                                                 981 - 1005
//

Text Mined References (6)

PMID Year Title