Tbio SLC16A12 Monocarboxylate transporter 12

Protein Summary

Description

Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane. This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q6ZSM3
• E9PSF9
• Q5M9M9
• Q5T7J2
• Q6ZV76
• MCT 12

Gene Name

• SLC16A12

Ensembl ID

• ENST00000371790
• ENSP00000360855
• ENSG00000152779

Symbol

• MCT12
• CJMG
• CRT2
• MCT12
• CTRCT47

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.7
gene perturbation	0.65
histone modification site profile	0.64
cell type or tissue	0.62
microRNA	0.62

Protein Classes

PANTHER Classes

Protein / Transporter / Monocarboxylate Transporter 12

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc16 Family Of Monocarboxylate Transporters / Monocarboxylate Transporter 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.63   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.63   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0