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Tbio
TIFAB
TRAF-interacting protein with FHA domain-containing protein B

Protein Summary
Description
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537858
  • ENSP00000440509
  • ENSG00000255833
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
tissue
0.61
cellular component
0.52
cell line
0.5
microRNA
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0