Tbio RNF19B E3 ubiquitin-protein ligase RNF19B

Protein Summary

Description

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q6ZMZ0
• B7ZLB2
• E9PAW6
• G3XA82
• Q0VG77
• Q5TH44
• Q5TH45
• Q6P6A4
• Q8N2S8
• Q8WUF3

Gene Name

• RNF19B

Ensembl ID

• ENST00000235150
• ENSP00000235150
• ENSG00000116514
• ENST00000356990
• ENSP00000349482
• ENST00000373456
• ENSP00000362555

Symbol

• IBRDC3
• NKLAM
• NKLAM
• IBRDC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.91
kinase perturbation	0.81
disease perturbation	0.79
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rnf19b

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rnf19b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.87   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.87   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0