Property Summary

NCBI Gene PubMed Count 16
PubMed Score 25.98
PubTator Score 11.93

Knowledge Summary

Patent (2,674)

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ependymoma 2514 4.3948399103017E-17
pediatric high grade glioma 2712 2.12838822158181E-10
lung adenocarcinoma 2714 2.82933483953208E-10
glioblastoma 5572 8.99702883135303E-8
atypical teratoid / rhabdoid tumor 4369 2.56278939992693E-7
sonic hedgehog group medulloblastoma 1482 2.78874825629401E-7
psoriasis 6685 7.8955828904513E-5
primitive neuroectodermal tumor 3031 2.66274728296307E-4
osteosarcoma 7933 4.66961220287704E-4
medulloblastoma, large-cell 6234 0.00132058495474248
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00161228546846862
lung cancer 4473 0.00424495722232538
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00698223443311166
astrocytic glioma 2241 0.0162730730146127
subependymal giant cell astrocytoma 2287 0.0356371425112077

Expression

Synonym

Accession Q6ZMQ8 O75136 Q6ZN31 Q86X28
Symbols LMR1
AATYK
LMTK1
p35BP
AATYK1
PPP1R77

Gene

PANTHER Protein Class (3)

  Ortholog (9)

 GWAS Trait (1)

Pathway (1)

Gene RIF (3)

PMID Text
25961023 Messenger RNAs for three proteins AATK, SLC27A1, and CDKAL1 are preferentially secreted out in exosomes from HIV-1 Nef-expressing cells, and their targeting miRNAs (miR-32 and miR-93*) are retained in these cells
17651901 This paper deals with the mouse ortholog.
14521924 Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.

AA Sequence

MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENAEG      1 - 70
DEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVF     71 - 140
LGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDL    141 - 210
KGYLRSCRVAESMAPDPRTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYR    211 - 280
EDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYT    281 - 350
VREQQLKLPKPQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG    351 - 420
GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRGAEAF    421 - 490
PATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPAAGHDPDCAGCAPSPPATADQ    491 - 560
DDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLARDPLCPSRSPSPSAGPLSLAEGGAEDADWG    561 - 630
VAAFCPAFFEDPLGTSPLGSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVS    631 - 700
AGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETAS    701 - 770
SGGDHPQAEPKLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL    771 - 840
ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPS    841 - 910
SASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEGPGPETRLS    911 - 980
TSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGS    981 - 1050
GPGEVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGP   1051 - 1120
PGLLSGPAPQKRMGGPGTPRAPLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEE   1121 - 1190
APAVPVVVAESQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK   1191 - 1260
ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPT   1261 - 1330
PAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA                             1331 - 1374
//

Text Mined References (18)

PMID Year Title
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22573681 2012 LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17651901 2007 Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family.
17344846 2007 Patterns of somatic mutation in human cancer genomes.
16969489 2006 Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14521924 2003 Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
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