Tbio GLDN Gliomedin

Protein Summary

Description

Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. This gene encodes a protein that contains olfactomedin-like and collagen-like domains. The encoded protein, which exists in both transmembrane and secreted forms, promotes formation of the nodes of Ranvier in the peripheral nervous system. Mutations in this gene cause a form of lethal congenital contracture syndrome in human patients. Autoantibodies to the encoded protein have been identified in sera form patients with multifocal motor neuropathy. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q6ZMI3
• Q6UXZ7
• Q7Z359

Gene Name

• GLDN

Ensembl ID

• ENST00000335449
• ENSP00000335196
• ENSG00000186417
• ENST00000396399
• ENSP00000379681
• ENST00000612989
• ENSP00000479249

Symbol

• COLM
• CLOM
• COLM
• CRGL2
• CRG-L2
• LCCS11
• UNC-112

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.95
microRNA	0.57
disease	0.46
cellular component	0.44
cell line	0.43

Protein Classes

PANTHER Classes

Protein / Structural Protein / Gliomedin

Protein / Receptor / Gliomedin

DTO Classes

Protein / Cellular Structure / Gliomedin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.64   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.64   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0