Tchem NAPRT Nicotinate phosphoribosyltransferase

Protein Summary

Description

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6XQN6
• A7BFI3
• Q6PJL1
• Q6XQN4
• Q6XQN5
• Q8N5E8
• Q9BRG0
• NAPRTase

Gene Name

• NAPRT

Ensembl ID

• ENST00000426292
• ENSP00000390949
• ENSG00000147813
• ENST00000449291
• ENSP00000401508
• ENST00000621955
• ENSP00000480017
• ENSG00000278488
• ENST00000632139
• ENSP00000488794

Symbol

• FHIP
• NAPRT1
• NAPRT1
• PP3856

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
pathway	0.8
tissue sample	0.58
transcription factor binding site profile	0.58
cell type or tissue	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Nicotinate Phosphoribosyltransferase

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Nicotinate Phosphoribosyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12