Tdark ASCL4 Achaete-scute homolog 4

Protein Summary

Description

Could be a transcriptional regulator involved in skin development. Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6XD76
• Q7RTS2
• ASH-4

Gene Name

• ASCL4

Ensembl ID

• ENST00000342331
• ENSP00000345420
• ENSG00000187855

Symbol

• BHLHA44
• HASH4
• HASH4
• bHLHa44

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.74
tissue	0.49
cell line	0.47
transcription factor	0.46
biological process	0.44

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Achaete-scute Homolog 4

Protein / Nucleic Acid Binding / Achaete-scute Homolog 4

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Achaete-scute Homolog 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0