Tdark ITIH6 Inter-alpha-trypsin inhibitor heavy chain H6

Protein Summary

Description

The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q6UXX5
• A6NN03

Gene Name

• ITIH6

Ensembl ID

• ENST00000218436
• ENSP00000218436
• ENSG00000102313

Symbol

• ITIH5L
• ITIH5L
• UNQ6369
• dJ14O9.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.52
cell line	0.51
microRNA	0.47
tissue	0.46
PubMedID	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.45   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 7   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.45   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0