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Tdark Trem-like transcript 4 protein


 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 3.73
PubTator Score 2.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 1.93757587956713E-6
ovarian cancer 8492 3.95091873181022E-5
osteosarcoma 7933 6.22991431839007E-4
diabetes mellitus 1663 0.00156157326959772
Disease Target Count Z-score Confidence
Ankylosing spondylitis 138 0.0 2.0

Expression

  Differential Expression (4)

Disease log2 FC p
osteosarcoma -1.013 0.001
diabetes mellitus 1.200 0.002
ovarian cancer -1.100 0.000
psoriasis 2.400 0.000

Synonym

Accession Q6UXN2 B7ZL92 TLT-4
Symbols TLT4
TLT-4

Gene

TREML4

  Ortholog (3)

Species Source
Chimp OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid

 GO Component (2)

 GO Process (1)

 Compartment GO Term (7)

 HCA RNA Cell Line (8)

Pathway (3)

 UniProt Keyword (8)

Gene RIF (2)

PMID Text
24975946 determined by von Kossa staining that TREML4 colocalizes with areas of microcalcification within coronary plaques. Overall, we present integrative RNA, DNA, and protein evidence implicating TREML4 in coronary artery calcification
20237496 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MAWGGVHTCCFHLCCCCSWPQGAVPEELHKHPGQTLLLQCQYSPKRGPYQPKSWCQQTSPSRCTLLVTSS      1 - 70
KPWTAVQKSHYTIWDKPNAGFFNITMIQLTQNDSGFYWCGIYNASENIITVLRNISLVVSPAPTTSPMWT     71 - 140
LPWLPTSTVLITSPEGTSGHPSINGSETRKSRAPACLGSGGPRFLVLVLCGLLLAKGLML              141 - 200
//

Text Mined References (7)

PMID Year Title
24975946 2014 Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12645956 2003 The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.