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Tbio
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

Protein Summary
Description
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320743
  • ENSP00000326759
  • ENSG00000139263
  • ENST00000379141
  • ENSP00000368436

Symbol
  • LIG3
  • LIG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.84
PubMedID
0.76
transcription factor binding site profile
0.76
tissue sample
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.03   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.03   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0