Tbio CCBE1 Collagen and calcium-binding EGF domain-containing protein 1

Protein Summary

Description

Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q6UXH8
• Q6MZX5
• Q86SS2
• Q8TF19

Gene Name

• CCBE1

Ensembl ID

• ENST00000439986
• ENSP00000404464
• ENSG00000183287
• ENST00000649564
• ENSP00000497183

Symbol

• KIAA1983
• HKLLS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
protein domain	0.85
microRNA	0.76
transcription factor perturbation	0.68
histone modification site profile	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Collagen And Calcium-binding Egf Domain-containing Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Collagen And Calcium-binding Egf Domain-containing Protein 1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Collagen And Calcium-binding Egf Domain-containing Protein 1

Protein / Cell Adhesion Molecule / Collagen And Calcium-binding Egf Domain-containing Protein 1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Collagen And Calcium-binding Egf Domain-containing Protein 1

Protein / Calcium-binding Protein / Annexin / Collagen And Calcium-binding Egf Domain-containing Protein 1

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Collagen And Calcium-binding Egf Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.07   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.07   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0