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Tbio Amelotin

Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 26.95
PubTator Score 5.36

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count Z-score Confidence
Amelogenesis imperfecta 26 5.098 2.5
Dental fluorosis 16 3.533 1.8
Exotropia 9 3.486 1.7

Expression

Synonym

Accession Q6UX39 Q0P503 Q0P506
Symbols UNQ689

Gene

AMTN

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid

 GO Component (3)

 GO Process (5)

 Compartment GO Term (10)

 HCA RNA Cell Line (19)

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 UniProt Keyword (10)

Gene RIF (2)

PMID Text
25407797 AMTN has a direct influence on biomineralization by promoting hydroxyapatite mineralization.
25158173 proinflammatory cytokines induce Amelotin gene transcription and a role for Amelotin in gingival inflammation

AA Sequence 

MRSTILLFCLLGSTRSLPQLKPALGLPPTKLAPDQGTLPNQQQSNQVFPSLSLIPLTQMLTLGPDLHLLN      1 - 70
PAAGMTPGTQTHPLTLGGLNVQQQLHPHVLPIFVTQLGAQGTILSSEELPQIFTSLIIHSLFPGGILPTS     71 - 140
QAGANPDVQDGSLPAGGAGVNPATQGTPAGRLPTPSGTDDDFAVTTPAGIQRSTHAIEEATTESANGIQ     141 - 209
//

Text Mined References (12)

PMID Year Title
25789606 2015 A secretory kinase complex regulates extracellular protein phosphorylation.
25407797 2015 The enamel protein amelotin is a promoter of hydroxyapatite mineralization.
25158173 2014 Transcriptional regulation of amelotin gene by proinflammatory cytokines in gingival fibroblasts.
21697133 2011 Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16787391 2006 Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium.
16304441 2005 Amelotin--a Novel Secreted, Ameloblast-specific Protein.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15340161 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
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