Tdark IGFL2 Insulin growth factor-like family member 2

Protein Summary

Description

Potential ligand of the IGFLR1 cell membrane receptor. IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6UWQ7
• E9PAV1
• Q6B9Z3

Gene Name

• IGFL2

Ensembl ID

• ENST00000377693
• ENSP00000366922
• ENSG00000204866
• ENST00000434646
• ENSP00000395219

Symbol

• UNQ645
• VPRI645

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.42
phenotype	0.33
interacting protein	0.31
tissue sample	0.28
transcription factor perturbation	0.27

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.25   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 47   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.25   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0