Property Summary

NCBI Gene PubMed Count 11
PubMed Score 20.98
PubTator Score 8.08

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 9.69815978905094E-20
non-small cell lung cancer 2798 8.79213278459497E-19
ovarian cancer 8492 6.97047807971284E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0460237046384169
Disease Target Count Z-score Confidence
Barth syndrome 23 3.383 1.7

Expression

  Differential Expression (4)

Disease log2 FC p
non-small cell lung cancer 1.194 0.000
intraductal papillary-mucinous neoplasm ... 1.200 0.046
lung carcinoma 1.300 0.000
ovarian cancer 1.300 0.001

Synonym

Accession Q6UWP7 A6H8Z7 Q8N1Q7
Symbols LYCAT
AGPAT8
ALCAT1
1AGPAT8
UNQ1849
HSRG1849

Gene

  Ortholog (15)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA EggNOG
C. elegans OMA Inparanoid

Gene RIF (2)

PMID Text
24779708 LYCAT expression was significantly altered in PBMCs and lung tissues from patients with idiopathic pulmonary fibrosis.
19075029 Data show that ALCAT1 possesses acyltransferase activities toward lysophosphatidylinositol and lysophosphatidylglycerol, and identify critical amino acids that are potentially involved in lysophospholipid substrate binding.

AA Sequence

MHSRGREIVVLLNPWSINEAVSSYCTYFIKQDSKSFGIMVSWKGIYFILTLFWGSFFGSIFMLSPFLPLM      1 - 70
FVNPSWYRWINNRLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYS     71 - 140
YLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTEN    141 - 210
SKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPHNIPQSEKHLLQGDFPRE    211 - 280
IHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKLLSI    281 - 350
LYWTLFSPAMCLLIYLYSLVKWYFIITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE          351 - 414
//

Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24779708 2014 The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
19946888 2010 Defining the membrane proteome of NK cells.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19075029 2009 The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.
17675553 2007 Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation.
16620771 2006 Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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