| Tdark | SLP adapter and CSK-interacting membrane protein |
Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation.
This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 4.9e-24 |
| lung adenocarcinoma | 2716 | 3.1e-05 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 3.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| lung adenocarcinoma | -1.100 | 3.1e-05 |
| lung carcinoma | -2.900 | 4.9e-24 |
| mucosa-associated lymphoid tissue lympho... | 2.776 | 3.5e-02 |
