Tdark | SLP adapter and CSK-interacting membrane protein |
Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation.
This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Comments
Disease | Target Count |
---|---|
Alzheimer's disease | 644 |
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 4.93964001384968E-24 |
lung adenocarcinoma | 2714 | 3.13928953344583E-5 |
mucosa-associated lymphoid tissue lymphoma | 480 | 0.0351978307327528 |
Disease | log2 FC | p |
---|---|---|
lung adenocarcinoma | -1.100 | 0.000 |
lung carcinoma | -2.900 | 0.000 |
mucosa-associated lymphoid tissue lympho... | 2.776 | 0.035 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
21930792 | results suggest that SCIMP is involved in signal transduction after MHC-II stimulation and therefore serves as a regulator of antigen presentation and other APC functions. |
PMID | Year | Title |
---|---|---|
24162737 | 2013 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. |
21930792 | 2011 | SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. |
18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
16625196 | 2006 | DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |