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Tdark Serine protease 55

Probable serine protease.

This gene encodes a member of a group of membrane-anchored chymotrypsin (S1)-like serine proteases. The enocoded protein is primarily expressed in the Leydig and Sertoli cells of the testis and may be involved in male fertility. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

 Comments

Property Summary

NCBI Gene PubMed Count 5
Grant Count 3
Funding $1,097,972
PubMed Score 3.86
PubTator Score 5.92

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (1)

Disease Z-score Confidence
Alzheimer's disease 644 1.0

Expression

Synonym

Accession Q6UWB4 E5RJX5
Symbols TSP1
CT153
T-SP1
UNQ9391

Gene

PRSS55

PANTHER Protein Class (3)

 Grant Application (3)

 GO Function (1)

 GO Component (2)

 Compartment GO Term (12)

 UniProt Keyword (14)

See all...

Gene RIF (1)

PMID Text
18844450 T-SP1 protein was detectable in prostate cancer and in some ovarian cancer tissues, indicating tumor-related synthesis of T-SP1

AA Sequence 

MLLFSVLLLLSLVTGTQLGPRTPLPEAGVAILGRARGAHRPQPPHPPSPVSECGDRSIFEGRTRYSRITG      1 - 70
GMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAHCLYSEELFPEELSVVLGTNDLTSPSMEIKEVA     71 - 140
SIILHKDFKRANMDNDIALLLLASPIKLDDLKVPICLPTQPGPATWRECWVAGWGQTNAADKNSVKTDLM    141 - 210
KAPMVIMDWEECSKMFPKLTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGKSCGEKN    211 - 280
TPGIYTSLVNYNLWIEKVTQLEGRPFNAEKRRTSVKQKPMGSPVSGVPEPGSPRSWLLLCPLSHVLFRAI    281 - 350
LY                                                                        351 - 352
//

Text Mined References (7)

PMID Year Title
23436708 2013 Scanning of novel cancer/testis proteins by human testis proteomic analysis.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
18844450 2008 T-SP1: a novel serine protease-like protein predominantly expressed in testis.
16421571 2006 DNA sequence and analysis of human chromosome 8.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.