Protein Summary
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
- ENST00000332112
- ENSP00000330375
- ENSG00000182585
- ENST00000413830
- ENSP00000411898
- ENST00000502358
- ENSP00000426678
- ENST00000503098
- ENSP00000425890
- ENST00000505212
- ENSP00000424392
- ENST00000509145
- ENSP00000426630
- ENST00000514968
- ENSP00000426550
- EPG
- PRO9904
- ALGV3072
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.97 | ||
biological process | 0.78 | ||
disease | 0.51 | ||
cellular component | 0.45 | ||
gene perturbation | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.54 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.54 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0