| Tbio | Epigen |
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Schistosomiasis | 38 | 6.516 | 3.3 |
| Clonorchiasis | 15 | 5.794 | 2.9 |
| Fascioliasis | 18 | 5.697 | 2.8 |
| Trichostrongylosis | 1 | 5.386 | 2.7 |
| Trichuriasis | 5 | 5.177 | 2.6 |
| Metagonimiasis | 2 | 5.055 | 2.5 |
| Hard palate cancer | 11 | 4.512 | 2.3 |
| Opisthorchiasis | 14 | 4.352 | 2.2 |
| Speech disorder | 7 | 4.256 | 2.1 |
| Capillariasis | 2 | 4.098 | 2.0 |
| Cleft palate | 125 | 4.077 | 2.0 |
| Ancylostomiasis | 6 | 3.814 | 1.9 |
| Ascariasis | 7 | 3.724 | 1.9 |
| Dicrocoeliasis | 1 | 3.571 | 1.8 |
| Anemia | 252 | 3.559 | 1.8 |
| Necatoriasis | 1 | 3.55 | 1.8 |
| Paragonimiasis | 9 | 3.437 | 1.7 |
| Gastroenteritis | 46 | 3.23 | 1.6 |
| Diarrhea | 155 | 3.199 | 1.6 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG |
| Cow | OMA EggNOG |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG |
| PMID | Year | Title |
|---|---|---|
| 22747683 | 2012 | Genetic variants associated with breast size also influence breast cancer risk. |
| 22610502 | 2012 | Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. |
| 22260327 | 2012 | EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. |
| 22193422 | 2012 | Autocrine epidermal growth factor receptor ligand production and cetuximab response in head and neck squamous cell carcinoma cell lines. |
| 21514161 | 2011 | Amphiregulin exosomes increase cancer cell invasion. |
| 19760033 | 2010 | The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer. |
| 17169360 | 2007 | Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17. |
| 16712791 | 2006 | Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. |
| 16469638 | 2006 | Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. |
| 15611079 | 2005 | Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. |
| More... |
