Tdark IGFL1 Insulin growth factor-like family member 1

Protein Summary

Description

Probable ligand of the IGFLR1 cell membrane receptor. The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q6UW32

Gene Name

• IGFL1

Ensembl ID

• ENST00000437936
• ENSP00000415823
• ENSG00000188293

Symbol

• UNQ644
• APRG644

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.47
microRNA	0.36
biological term	0.35
interacting protein	0.31
tissue sample	0.26

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.82   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.82   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0