Tbio CYP20A1 Cytochrome P450 20A1

Protein Summary

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6UW02
• Q4ZG61
• Q8N4Q8
• Q8WWA9
• Q9HC04

Gene Name

• CYP20A1

Ensembl ID

• ENST00000356079
• ENSP00000348380
• ENSG00000119004

Symbol

• CYP-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
transcription factor binding site profile	0.69
tissue sample	0.67
small molecule perturbation	0.6
cell line	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.55   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0