Tchem KCNT2 Potassium channel subfamily T member 2

Protein Summary

Description

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).

Uniprot Accession IDs

• Q6UVM3
• Q3SY59
• Q5VTN1
• Q6ZMT3

Gene Name

• KCNT2

Ensembl ID

• ENST00000294725
• ENSP00000294725
• ENSG00000162687
• ENST00000367433
• ENSP00000356403
• ENST00000609185
• ENSP00000476657

Symbol

• SLICK
• SLICK
• EIEE57
• KCa4.2
• SLO2.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
gene perturbation	0.74
histone modification site profile	0.72
phenotype	0.68
tissue sample	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Calcium-activated Subfamily / Kca4.2/kcnt2 Sub-subfamily / Potassium Channel Subfamily T Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2